Karen Leth Nielsen

Resistance to antibacterial peptide nucleic acids through altered ribosome function

This study identifies a ribosome-centered mechanism of resistance to antibacterial PNAs in E. coli, showing that mutations in ribosomal protein uS12 alter 30S assembly and translation-initiation dynamics, reducing PNA efficacy.

The antimycotic 5-fluorocytosine is a virulence inhibitor of uropathogenic Escherichia coli and eradicates biofilm-embedded bacteria synergizing with β-lactams

This paper shows that 5-fluorocytosine inhibits biofilm formation and virulence in uropathogenic E. coli and synergizes with β-lactams to eradicate biofilm-embedded bacteria.