Hybrid quantum-classical de novo design of MHC-binding peptides
Emilie Sofie Engdal, Jonathan Funk, Omar Bacarreza, Laura Machado, Kristoffer Haurum Johansen, Janine Sophie Kemming, Thorin Farnsworth, Valentas Brasas, Rodrigue Yves Louis Lefèvre‐Morand, Mateusz Slysz, Oliver Luscombe Noerregaard, Oliver August Dall’Alba Sandberg, Alexander Makarovskiy, Peter Lodahl, Carlos G. Acevedo‐Rocha, , Timothy P. Jenkins
This paper introduces a hybrid quantum-classical pipeline for designing MHC-binding peptides, showing that quantum-derived priors improve the yield of strong binders, especially for understudied HLA alleles.
bioRxiv · Jul 10, 2026 · PreprintBiochemistry