Trem2hi macrophages bridge inflammation resolution and fibrosis initiation after ischemia-reperfusion injury in the kidney
Yan Tong, Fangxin Mu, Chao Wang, Tian Sang, Xuefeng Sun, Zhe Feng, Guangyan Cai, Xiangmei Chen, Qing Ouyang
This study identifies Trem2hi macrophages as mediators bridging inflammation resolution and fibrosis initiation after kidney injury, showing their role in promoting fibrosis through specific mechanisms.
bioRxiv · Mar 19, 2026 · PreprintImmunology