Author

Tiffany Shields

Vanderbilt University Medical Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:variant effect prediction· 3 Approach:experimental assay· 2 Research Focus:database / resource· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Assay:electronic health records· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Andrew Michael GlazeriD· 3 shared Brett M. KronckeiD· 3 shared Dan M. RodeniD· 3 shared Laura L ShortiD· 2 shared Lynn D. HalliD· 2 shared Yuko WadaiD· 2 shared Ayesha MuhammadiD· 1 shared Bian LiiD· 1 shared

Activity by Year

2019-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersGenetics

Andrew Michael GlazerORCID

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Author profile →

3 papers

Recent·Most cited

High-throughput reclassification of SCN5A variants

Andrew Michael Glazer, Yuko Wada, Bian Li, Ayesha Muhammad, Olivia R. Kalash, Matthew J. O’Neill, Tiffany Shields, Lynn D. Hall, Laura L Short, Marcia A. Blair, Brett M. Kroncke, John A. Capra, Dan M. Roden

This study reclassifies SCN5A variants using high-throughput patch clamping, finding most variants of uncertain significance are either benign or pathogenic.

The American Journal of Human Genetics · Jun 12, 2020Peer-reviewedGenetics

Deep Mutational Scan of a cardiac sodium channel voltage sensor

Andrew Michael Glazer, Brett M. Kroncke, Kenneth A. Matreyek, Tao Yang, Yuko Wada, Tiffany Shields, Joe‐Elie Salem, Douglas M. Fowler, Dan M. Roden

The paper performs a deep mutational scan of SCN5A variants to assess their functional impact, identifying 40 gain and 33 loss of function variants with high accuracy.

bioRxiv · Sep 18, 2019 · PreprintGenetics

A rare variant on a common risk haplotype of HFE causes increased risk of hereditary hemochromatosis

Andrew Michael Glazer, Lisa A. Bastarache, Lynn D. Hall, Laura L Short, Tiffany Shields, Brett M. Kroncke, Joshua C. Denny, Dan M. Roden

The paper identifies HFE E168Q as a novel pathogenic variant associated with hereditary hemochromatosis using Phenotype Risk Scores and validates its mechanism through experimental assays.

bioRxiv · Feb 12, 2019 · PreprintGenetics