Alpha-1 Antitrypsin Overexpressing Mesenchymal Stem/Stromal Cells Reverses Type 1 Diabetes via Promoting Treg Function and CD8+ T cell exhaustion
Hua Wei, Wenyu Gou, Judong Kim, Suganya Subramanian, Tiffany Yeung, Paramita Chakraborty, Shikhar Mehrotra, Stefano Berto, Charlie Strange, Hongjun Wang
This study shows that AAT-overexpressing MSCs reverse T1D in NOD mice by enhancing Treg function and inducing CD8+ T cell exhaustion.
bioRxiv · Apr 19, 2025 · PreprintCell Biology