Inversely proportional myelin growth due to altered Pmp22 gene dosage identifies PI3K/Akt/mTOR signaling as a novel therapeutic target in HNPP
Doris Krauter, David Ewers, Timon J Hartmann, Stefan Volkmann, Theresa Kungl, Robert Fledrich, Sandra Goebbels, Klaus‐Armin Nave, Michael Werner Sereda
This study identifies PI3K/Akt/mTOR signaling as a therapeutic target for HNPP by showing that mTOR inhibitors reduce hypermyelination in HNPP mouse models.
bioRxiv · Nov 8, 2021 · PreprintNeuroscience