Opposing effects of H2A.Z on memory, transcription and pathology in male and female Alzheimer's disease mice and patients
Jian Luo, Luca A. Hategan, Samantha D. Creighton, Shan Hua, Timothy A. B. McLean, Tarkan Ahmad Dahi, Zhenhong Jin, Fardad Pirri, Stephen M. Winston, Isaiah L. Reeves, Margaret L. Fahnestock, Mark A. Brimble, Brandon J. Walters, Patrick J. Murphy, Iva B. Zovkic
This study shows H2A.Z has opposite effects on memory and pathology in male and female Alzheimer's disease mice and patients, indicating sex-specific roles in disease progression.
bioRxiv · May 28, 2025 · PreprintNeuroscience