Stephen M. Winston

Deconstruction of a memory engram reveals distinct ensembles recruited at learning

This study identifies distinct neuronal ensembles in dorsal CA1 that are differentially active during associative fear memory acquisition and reveals which ensembles form the core engram.

Extinction and subsequent updating of innate fear responses to a visual looming stimulus rely on hippocampus-dependent mechanisms

The paper shows that innate fear responses to visual looming stimuli in mice can be reduced through repeated exposure and that hippocampal engrams are required for learned fear responses.

Opposing effects of H2A.Z on memory, transcription and pathology in male and female Alzheimer's disease mice and patients

This study shows H2A.Z has opposite effects on memory and pathology in male and female Alzheimer's disease mice and patients, indicating sex-specific roles in disease progression.