Patrick J. Murphy

Ablation and Seed-driven Restoration of an Alpha-Satellite Devoid Human Centromere Reveals Size Homeostasis Mechanisms

This study uses a genetically tractable neocentromere system to show that centromere formation involves a seed-driven expansion process and size homeostasis mechanisms.

H2A.Z levels control the timing of major events at the maternal-zygotic transition

This study shows that H2A.Z levels act as a timer for the maternal-zygotic transition in Drosophila and zebrafish, influencing developmental timing through both nuclear and non-nuclear mechanisms.

Opposing effects of H2A.Z on memory, transcription and pathology in male and female Alzheimer's disease mice and patients

This study shows H2A.Z has opposite effects on memory and pathology in male and female Alzheimer's disease mice and patients, indicating sex-specific roles in disease progression.

CUT&Tag Identifies Repetitive Genomic Loci that are Excluded from ChIP Assays

The paper compares ChIP-Seq and CUT&Tag for chromatin modification detection, finding CUT&Tag better captures repetitive elements and heterochromatin regions.

Anp32e protects against accumulation of H2A.Z at Sox motif containing promoters during zebrafish gastrulation

The paper shows that Anp32e limits H2A.Z accumulation at Sox motif promoters during zebrafish gastrulation, enabling timely gene expression.

Competition for H2A.Z between genes and repetitive elements establishes response to anti-viral immune activation

The paper shows that H2A.Z levels influence sensitivity to retroviral activation by shifting its distribution between gene promoters and repetitive elements in zebrafish embryos.

Establishment of Developmental Gene Silencing by Ordered Polycomb Complex Recruitment in Early Zebrafish Embryos

The paper shows how developmental gene silencing is established in zebrafish embryos through H2Aub1 deposition by Rnf2-PRC1, followed by Aebp2-PRC2 recruitment and H3K27me3 deposition.

Identification of chromatin states during zebrafish gastrulation using CUT&RUN and CUT&Tag

The paper applies CUT&RUN and CUT&Tag to zebrafish gastrulation embryos to map chromatin states and identify developmental gene regulation patterns.

Genome-wide Chromatin Accessibility is Restricted by ANP32E

The paper shows ANP32E restricts genome-wide chromatin accessibility by regulating H2A.Z localization in mouse fibroblasts.

Oxidative stress underlies heritable impacts of paternal cigarette smoke exposure

This study shows paternal cigarette smoke exposure alters sperm DNA methylation and offspring gene expression, with oxidative stress mediating these heritable changes.

Maintenance of spatial gene expression by Polycomb-mediated repression after formation of a vertebrate body plan

The paper shows that Polycomb-mediated repression maintains spatial gene expression in zebrafish after body plan formation, with minimal global changes in gene expression.

Placeholder nucleosomes underlie germline-to-embryo DNA methylation reprogramming

The paper identifies Placeholder nucleosomes in zebrafish that prevent DNA methylation and regulate gene activation during early embryonic development.