Author

Timothy Hardman

Duke University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetic & Genomic Medicine· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Research Focus:variant calling· 2 Assay:whole-exome sequencing· 2 Research Focus:benchmarking· 1 Approach:machine learning (classical)· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Angelo FortunatoiD· 2 shared Carlo C. MaleyiD· 2 shared Diego MalloiD· 2 shared E. Shelley HwangiD· 2 shared Jeffrey R. MarksiD· 2 shared Lorraine M. KingiD· 2 shared Abeer M. ShaabaniD· 1 shared Ahmed A. AhmediD· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersGenetic & Genomic Medicine

Angelo FortunatoORCID

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2 papers

Recent·Most cited

Genomic profiling defines variable clonal relatedness between invasive breast cancer and primary ductal carcinoma in situ

Esther H. Lips, Tapsi Kumar, Anargyros Megalios, Lindy L. Visser, Michael Sheinman, Angelo Fortunato, Vandna Shah, Marlous Hoogstraat, Emi Sei, Diego Mallo, Maria Roman-Escorza, Ahmed A. Ahmed, Mingchu Xu, Alexandra W. van den Belt‐Dusebout, Wim Brugman, , Elinor J. Sawyer

The paper uses genomic profiling to show that some invasive breast cancers are clonally unrelated to their preceding DCIS, suggesting DCIS may act as both a precursor and independent risk factor.

Nature Genetics · Jun 1, 2022Peer-reviewedGenetic & Genomic Medicine

A new method to accurately identify single nucleotide variants using small FFPE breast samples.

Angelo Fortunato, Diego Mallo, Shawn M. Rupp, Lorraine M. King, Timothy Hardman, Joseph Yuan-Chieh Lo, Allison H. S. Hall, Jeffrey R. Marks, E. Shelley Hwang, Carlo C. Maley

This paper develops and validates a new bioinformatic algorithm to accurately identify somatic SNVs from small DNA amounts in FFPE breast cancer samples, showing improved performance over existing methods.

Briefings in Bioinformatics · May 22, 2021Peer-reviewedGenomics