Lindy L. Visser

Lineage-associated tumor cell states predict outcome and guide immunotherapeutic target selection in pediatric osteosarcoma

This study identifies lineage-associated tumor cell states in pediatric osteosarcoma that correlate with clinical outcomes and guide immunotherapeutic target selection.

Blocking MIF secretion enhances CAR T-cell efficacy against neuroblastoma

This study identifies MIF as a key immunosuppressive factor in neuroblastoma that inhibits CAR T-cell efficacy, showing that blocking MIF enhances T-cell activation and therapeutic potential.

Genomic profiling defines variable clonal relatedness between invasive breast cancer and primary ductal carcinoma in situ

The paper uses genomic profiling to show that some invasive breast cancers are clonally unrelated to their preceding DCIS, suggesting DCIS may act as both a precursor and independent risk factor.