MicrobiologyThe ISME JournalPeer-reviewed
Dynamics of drug delivery determines course of evolution of antibiotic responses in bacteria
John C Crow, Hao Geng, Christopher J. Geiger…·Daniel Schultz
This study shows that the dynamics of antibiotic exposure influence the type of mutations that evolve in bacteria, with gradual exposure leading to adaptive mutations and periodic exposure causing loss of regulatory control.
11 citations