Shannon M. Soucy

The paper shows that ileitis disrupts bile acid (BA) pool balance, altering immune regulation by affecting BA receptor interactions and Th17 cell function.

This study investigates microbial dysbiosis in children with cystic fibrosis, identifying glycerol as a driver of altered microbial competition and linking colibactin production to increased colorectal cancer risk.

This study compares RNA extraction and preservation protocols for miRNA profiling in infant and toddler stool, finding that RNAlater and Zymo DNA/RNA Shield yield similar high-quality RNA with comparable human miRNA profiles.

This study profiles bile acids in stool from children with and without cystic fibrosis, revealing differences in BA species and microbial metabolism, and highlights the ferret model's suitability for BA research in CF.

This study identifies mitochondrial oxidative phosphorylation as a metabolic vulnerability in endocrine-tolerant persister ER+ breast cancer cells, suggesting therapeutic targeting of mitochondrial function could prevent recurrence.

This study shows that the dynamics of antibiotic exposure influence the type of mutations that evolve in bacteria, with gradual exposure leading to adaptive mutations and periodic exposure causing loss of regulatory control.

The paper quantifies ileal bile acid pools in mice and shows that Asbt-mediated transport dominates their size and composition, with loss of Asbt reducing pool size and altering transcriptional responses.