The Discovery of Small Molecule Inhibitors of cFLIP that Sensitise Tumour Cells to TRAIL
Gilda Giancotti, Rhiannon French, Olivia A. Hayward, Kok Yung Lee, Timothy Robinson, Andreia M. Ribeiro da Silva, Athina Varnava, Marion MacFarlane, Richard W. E. Clarkson, Andrew D. Westwell, Andrea Brancale
This paper identifies small molecule inhibitors of cFLIP that enhance TRAIL-induced apoptosis in breast cancer cells and improves their potency through structure-activity relationship studies.
Academia oncology. · Apr 29, 2025Peer-reviewedCancer Biology