Andrea Brancale

This paper identifies a new class of thiophen-2-yl pyrimidines (TPPs) with improved solubility and potency against Schistosoma species, suggesting novel targets beyond tubulin.

The paper demonstrates the use of photoaffinity labeling in Schistosoma mansoni to identify protein-ligand interactions, showing specific tubulin labeling and potential for drug target discovery.

This paper identifies small molecule inhibitors of cFLIP that enhance TRAIL-induced apoptosis in breast cancer cells and improves their potency through structure-activity relationship studies.

This study identifies quinoxaline-based anti-schistosomal compounds with potent anti-malarial activity against Plasmodium falciparum, including resistance mechanisms involving pfqrp1 and pfatp2.

This study identifies two quinoxaline derivatives with potent antibacterial activity against MRSA, VRE, and their biofilms, showing comparable or better efficacy than existing antibiotics.