Rapid Determination of Drug-to-Antibody Ratios in Antibody Drug Conjugates Using Ultrafast Microdroplet Digestion Technology
Yongqing Yang, Juana Perez Sancheza, Timothy Yaroshuk, M. Hassan, Praneeth Ivan Joel Fnu, Thomas Walker, Jim Lau, Mike Knierman, Hui Zhao, Xi Qiu, Karen Yao Luo, Harsha P. Gunawardena, Baatar Munkhtsetseg, Hao Chen
This paper introduces an ultrafast microdroplet digestion-mass spectrometry method for rapid and accurate determination of drug-to-antibody ratios in ADCs.
bioRxiv · Jun 5, 2026 · PreprintBiochemistry