M. Hassan

Rapid Determination of Drug-to-Antibody Ratios in Antibody Drug Conjugates Using Ultrafast Microdroplet Digestion Technology

This paper introduces an ultrafast microdroplet digestion-mass spectrometry method for rapid and accurate determination of drug-to-antibody ratios in ADCs.

Delineating the heterogeneity of senescence-induced-functional alterations inhepatocytes

This study investigates how different stressors induce distinct senescence markers and bioenergetic changes in mouse hepatocytes and liver organoids.

Single-Cell Transcriptomic Profiling Unveils Critical Metabolic Alterations and Signatures in Progression of Atherosclerosis

This study uses single-cell RNA sequencing to identify metabolic changes and gene signatures in atherosclerosis progression, revealing altered metabolic pathways and cell-cell interactions.

A multi-omics analysis of glioma chemoresistance using a hybrid microphysiological model of glioblastoma

This study uses a hybrid microphysiological model to analyze glioma chemoresistance and identifies molecular changes associated with resistance mechanisms.

NOTCH-YAP1/TEAD-DNMT1 axis regulates hepatocytereprogramming into intrahepatic cholangiocarcinoma

The paper identifies a NOTCH-YAP1/TEAD-DNMT1 axis that drives hepatocyte reprogramming into intrahepatic cholangiocarcinoma and reveals its role in tumor development.

Clinical and genomic epidemiology of carbapenem-non-susceptible Citrobacter spp. at a tertiary healthcare center over two decades

The paper analyzes the clinical and genomic epidemiology of carbapenem-non-susceptible Citrobacter spp. over two decades, finding increased prevalence and genetic diversity with carbapenemase-encoding plasmids.

FxR-modulates the gut-vascular barrier by regulating the entry sites for bacterial translocation in experimental cirrhosis

This study shows that FXR agonists reduce bacterial translocation in cirrhosis by stabilizing the gut-vascular barrier and mucus layer.