Magnetic Tweezers Experiments Reveal Increased Mechanical Sensitivity of the F2561Y Mutant in Von Willebrand Factor
Caroline Körösy, Stefanie D. Pritzl, Tobias Obser, Maria Alexandra Brehm, Jan Lipfert
This study uses magnetic tweezers to show the F2561Y mutation in VWF lowers stem opening force and increases open conformations, explaining its prothrombotic effects.
Journal of Molecular Biology · Sep 21, 2026Peer-reviewedBiophysics