Jan Lipfert

This paper introduces MARs, magnetic molecular nanorulers that measure molecular distances and enable combinatorial biosensing with high accuracy and resolution.

CALISTO calibrates magnetic tweezers forces using three thermal-motion-based methods, improving accuracy by filtering problematic data.

This study uses magnetic tweezers to show the F2561Y mutation in VWF lowers stem opening force and increases open conformations, explaining its prothrombotic effects.

The paper determines the molecular structures of SYTOX Orange and SYTOX Green, characterizes their effects on DNA mechanics using magnetic tweezers, and reports their photophysical properties.

This paper demonstrates magnetic DNA origami nanorotors that can be controlled and rotated using magnetic fields, achieving torque values of 10-100 pN nm.

This study measures DNA twist at high salt concentrations using magnetic tweezers and simulations, showing ion-specific changes but no evidence for a C-form transition.

This paper investigates how DMSO affects DNA structure and mechanics using single-molecule techniques and simulations, finding that DMSO increases DNA flexibility and compaction up to 50% concentration.

This paper introduces NanoRCS, a method using nanopore sequencing and consensus calling to accurately estimate tumor fractions from cfDNA by analyzing SNVs, CNAs, and fragmentomics.

This study introduces AXSI for measuring absolute intramolecular distances in proteins, validated against single-molecule FRET, showing its effectiveness under various solution conditions.

This paper introduces a drift-invariant force calibration method for multiplexed magnetic tweezers using Hadamard variance, showing higher precision and accuracy than existing techniques.

The paper uses coarse-grained simulations and unsupervised learning to study protein-mediated DNA compaction, finding that protein-protein interactions are critical for forming looped structures observed experimentally.

This study examines how H3K36me3 and H4K5/8/12/16ac histone modifications affect nucleosome structure and interactions in tri-nucleosome arrays, revealing distinct mechanisms for inducing open conformations.

This study shows HIV integrase compacts viral DNA into biphasic condensates, with the core susceptible to inhibitors and the outer layer resistant.

This study uses high-throughput AFM imaging to analyze how histone modifications affect nucleosome structure, finding that H3K36me3 increases unwrapping while others act through higher-order processes.