Chromosomal instability shapes the tumor microenvironment of esophageal adenocarcinoma via a cGAS-chemokine-myeloid axis
Bruno Beernaert, Rose L. Jady‐Clark, Parin Shah, Erik Ramon‐Gil, Nora M. Lawson, Zack D Brodtman, Somnath Tagore, Frederik Stihler, A. Carter, Shannique Clarke, Tong Liu, Winston M. Zhu, Juliet E. Martin, Erkin Erdal, Alistair Easton, , Eileen E. Parkes
This study shows that chromosomal instability in esophageal adenocarcinoma drives an inflammatory tumor microenvironment through a cGAS-chemokine-myeloid axis, with CXCL8 as a key mediator.
Science Advances · Mar 11, 2026Peer-reviewedCancer Biology