Author

Bruno Beernaert

University of OxfordORCID 0000-0002-6219-6163Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Genetic & Genomic Medicine· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Organism:human· 2 Assay:spatial transcriptomics· 2 Research Focus:benchmarking· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

Eileen E. ParkesiD· 3 shared Kadir Caner AkdemiriD· 2 shared Nora M. LawsoniD· 2 shared A. CarteriD· 1 shared Alistair EastoniD· 1 shared Amit GroveriD· 1 shared Andréa E. TijhuisiD· 1 shared Archit GuptaiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersCancer Biology

Eileen E. ParkesORCID

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3 papers

Recent·Most cited

Cancer BiologyScience AdvancesPeer-reviewedMar 11, 2026

Chromosomal instability shapes the tumor microenvironment of esophageal adenocarcinoma via a cGAS-chemokine-myeloid axis

Bruno Beernaert, Rose L. Jady‐Clark, Parin Shah…·Eileen E. Parkes

This study shows that chromosomal instability in esophageal adenocarcinoma drives an inflammatory tumor microenvironment through a cGAS-chemokine-myeloid axis, with CXCL8 as a key mediator.

11 citationstop 1%

humanspatial transcriptomics

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ImmunologybioRxivPreprintJan 2, 2026

TMEM33 deletion potentiates anti-tumor CD8+ T cell immunity

Matthew P. Jackson, T. Zhao, Gusztav Milotay…·Eileen E. Parkes

This study shows TMEM33 limits progenitor-exhausted CD8+ T cells, enhances anti-tumor responses, and correlates with improved survival in melanoma patients.

DOI 10.64898/2026.01.01.697288

mousebulk RNA-seq

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Genetic & Genomic MedicinemedRxivPreprintFeb 19, 2025

Recurrent ERBB2 alterations are associated with esophageal adenocarcinoma brain metastases

Nora M. Lawson, Lingqun Ye, Chae Yun Cho…·Kadir Caner Akdemir

The paper identifies ERBB2 alterations as a recurrent oncogene in esophageal adenocarcinoma brain metastases and links them to monoclonal seeding and treatment response.

2 citations

humanwhole-genome sequencing

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