A high-content imaging workflow to screen for molecules that reduce cellular uptake of α-synuclein preformed fibrils
Wolfgang Reintsch, Andrea I. Krahn, Chanshuai Han, Emmanuelle Nguyen, Carol X.‐Q. Chen, Wen Luo, Irina Shlaifer, Tom Pfeifer, Edward A. Fon, Thomas M. Durcan
The paper describes a high-content imaging assay to screen small molecules that reduce cellular uptake of α-synuclein preformed fibrils in hiPSC-derived cells, identifying compounds that effectively lower intracellular PFF load.
Methods · May 5, 2026Peer-reviewedNeuroscience