Elucidating conformational alteration of human islet amyloid polypeptide by nonsynonymous substitution
Md Abul Bashar, Largess Barua, Supti Paul, Nayan Dash, Toma Sadhu, Sarmistha Mitra, Raju Dash
This study identifies deleterious nonsynonymous variants in human islet amyloid polypeptide (IAPP) and shows how they alter its conformational dynamics, potentially contributing to type 2 diabetes and protein misfolding disorders.
bioRxiv · Nov 16, 2024 · PreprintBiophysics