Competition between protein-RNA clustering and phase separation drives re-entrant phase behavior of hnRNPA1
Katarzyna Makasewicz, Chiara Morelli, Tommaso Guida, Lenka Faltova, Paolo Arosio
This study shows that hnRNPA1 phase separation is suppressed at high RNA concentration due to competition with protein-RNA cluster formation, with specific RNAs promoting clusters more effectively than unspecific ones.
Nature Communications · Apr 28, 2026Peer-reviewedBiophysics