Lenka Faltova

De novo design of peptides localizing at the interface of biomolecular condensates

This study designs peptides that localize at biomolecular condensate interfaces using a computational pipeline combining simulations, machine learning, and optimization, revealing charge-dependent localization mechanisms.

Competition between protein-RNA clustering and phase separation drives re-entrant phase behavior of hnRNPA1

This study shows that hnRNPA1 phase separation is suppressed at high RNA concentration due to competition with protein-RNA cluster formation, with specific RNAs promoting clusters more effectively than unspecific ones.

Enhancement of Enzymatic Activity by Biomolecular Condensates through pH Buffering

This study shows that biomolecular condensates enhance enzymatic activity by buffering pH, allowing enzymes to function effectively in acidic conditions and enabling pH-dependent cascade reactions.