Matrix mechanotransduction mediated by thrombospondin-1/integrin/YAP signaling pathway in the remodeling of blood vessels
Yoshito Yamashiro, Bui Quoc Thang, Karina Ramirez, Seung Jae Shin, Tomohiro Kohata, Shigeaki Ohata, Tram Anh Vu Nguyen, Sumio Ohtsuki, Kazuaki NAGAYAMA, Hiromi Yanagisawa
This study identifies thrombospondin-1 as a mediator of matrix mechanotransduction in vascular remodeling, showing its role in integrin signaling and YAP nuclear shuttling under mechanical stress.
Proceedings of the National Academy of Sciences · Apr 22, 2020Peer-reviewedMolecular Biology