Sumio Ohtsuki

The paper identifies the Hitchdock domain in kinesin-2 tail as critical for adaptor assembly and cargo binding, revealing its structural role in interactions with KAP3 and APC.

This study identifies G protein-biased LPAR1 agonism as a mechanism underlying the antidepressant effects of TCAs like amitriptyline, distinguishing them from SSRIs.

The paper introduces a water droplet-in-oil digestion method for single-cell proteomics that improves protein and peptide recovery and enables quantification of 462 proteins from 100 cells.

This study identifies thrombospondin-1 as a mediator of matrix mechanotransduction in vascular remodeling, showing its role in integrin signaling and YAP nuclear shuttling under mechanical stress.