Hiromi Yanagisawa

In vivo effects of inducible transgene expression of the age-associated glycogenes St6gal1 and Man1a on epidermal homeostasis

This study investigates the in vivo effects of St6gal1 and Man1a glycogenes on epidermal homeostasis in mice, finding distinct impacts on proliferation, inflammation, and glycosylation patterns.

The epidermal stem cell-supporting matricellular protein fibulin 7 modulates skin inflammatory response in a psoriasis model

This study shows fibulin 7 protects against skin inflammation by modulating IL-17A signaling in a psoriasis model.

Dermal bone grows by cellular invasion and intercalary biomineralization

The paper reveals that dermal bone growth involves cellular invasion and intercalary biomineralization, challenging the traditional model of matrix apposition by superficial osteoblasts.

Dermal bone remodelling by invasive osteoblasts evolved in stem gnathostomes

The paper identifies a common lineage origin of endothelial cells and osteoblasts and reveals de novo vasculogenesis as a key mechanism in dermal bone remodeling in vertebrates.

Immunomodulatory mechanisms of submicron phosphatidylserine-exposing polymeric particles (PSPs)

This study develops submicron phosphatidylserine-exposing polymeric particles (PSPs) that modulate macrophage activity by reducing inflammation and promoting resolution through redox adaptation and suppression of inflammatory signaling.

Osteopontin Upregulation Defines a Pre-Rupture State in Thoracic Aortic Aneurysms in Mice and Humans

The paper identifies osteopontin (OPN) upregulation as a conserved molecular signature of the pre-rupture state in thoracic aortic aneurysms across mice and humans.

Integrin-binding matricellular protein fibulin-5 maintains epidermal stem cell heterogeneity during skin aging

This study shows that fibulin-5 maintains epidermal stem cell heterogeneity during aging by regulating integrin expression and YAP signaling.

Spatiotemporal dynamics of CD73 in mouse retina under physiological conditions

This study examines the spatiotemporal expression of CD73 in the mouse retina across development and adulthood, revealing its role in retinal function and adenosine signaling.

A novel genetic mouse model of fatal aortic dissection reveals massive inflammatory cell infiltration in the thoracic aorta

This paper introduces a novel genetic mouse model of aortic dissection showing immune cell infiltration and altered ECM dynamics.

Defining epithelial stem cell heterogeneity through undulating structures of the skin and oral mucosa

This study investigates how undulating tissue structures influence epithelial stem cell heterogeneity in skin and oral mucosa using mouse models and 3D culture systems.

The extracellular matrix fibulin 7 maintains epidermal stem cell heterogeneity during skin aging

This study shows that fibulin 7 maintains epidermal stem cell heterogeneity during skin aging by preserving fast-cycling clones and preventing inflammation-related gene expression.

Partial endothelial-to-mesenchymal transition (EndMT) contributes to lumen re-organization after carotid arteryligation

This study identifies partial endothelial-to-mesenchymal transition (EndMT) as a mechanism contributing to lumen re-organization after carotid artery ligation.

Defining compartmentalized stem and progenitor populations with distinct cell division frequency in the ocular surface epithelium

The paper identifies compartmentalized stem and progenitor populations in the ocular surface epithelium with distinct division frequencies using lineage tracing in mice.

Matrix mechanotransduction mediated by thrombospondin-1/integrin/YAP signaling pathway in the remodeling of blood vessels

This study identifies thrombospondin-1 as a mediator of matrix mechanotransduction in vascular remodeling, showing its role in integrin signaling and YAP nuclear shuttling under mechanical stress.