Metabolite accumulation from oral NMN supplementation drives aging-specific kidney inflammation
Tara A. Saleh, Jeremy D. Whitson, Phoebe Keiser, Praveena Prasad, Brenita C. Jenkins, Tori Sodeinde, Carolyn N. Mann, Peter S. Rabinovitch, Melanie R. McReynolds, Mariya T. Sweetwyne
This study shows that NMN supplementation in aged mice increases kidney inflammation and uremic toxins, suggesting age-specific risks of NAD+ boosting supplements.
bioRxiv · Apr 9, 2024 · PreprintPhysiology