Mariya T. Sweetwyne

This study isolates podocyte mitochondria from mice to show they have higher respiratory capacity than tubule mitochondria, with age- and sex-dependent differences.

The paper identifies age-related molecular changes in mouse spleens using proteomics and transcriptomics, showing cell-type-specific remodeling and gender differences in post-transcriptional buffering.

The paper compares mitochondrial interactomes of podocytes and tubules in mouse kidney using quantitative cross-linking mass spectrometry, revealing distinct pathways and enzyme activities.

This study shows that NMN supplementation in aged mice increases kidney inflammation and uremic toxins, suggesting age-specific risks of NAD+ boosting supplements.

The paper detects age-related tissue-specific accumulation of mtDNA mutations in mice and shows oxidative damage mutations are reduced with treatment.

The paper identifies a mutational gradient in mtDNA that correlates with replication and influences mutation accumulation and genome composition.