Peter S. Rabinovitch

This study shows that NMN supplementation in aged mice increases kidney inflammation and uremic toxins, suggesting age-specific risks of NAD+ boosting supplements.

The paper detects age-related tissue-specific accumulation of mtDNA mutations in mice and shows oxidative damage mutations are reduced with treatment.

The paper identifies a mutational gradient in mtDNA that correlates with replication and influences mutation accumulation and genome composition.

This study identifies SS-31 interacting proteins in mitochondria using chemical cross-linking and mass spectrometry, revealing their roles in ATP production and 2-oxoglutarate metabolism.