MARK4 with an Alzheimer's disease-related mutation promotes tau hyperphosphorylation directly and indirectly and exacerbates neurodegeneration
Toshiya Oba, Taro Saito, Akiko Asada, Sawako Shimizu, Koichi Iijima, Kanae Ando
This study shows that a MARK4 mutation linked to Alzheimer's disease increases tau phosphorylation and neurodegeneration through both direct and indirect mechanisms.
bioRxiv · May 20, 2020 · PreprintNeuroscience