Koichi Iijima

This study shows that axonal mitochondria depletion disrupts autophagy and proteostasis in neurons, mediated by the eIF2β pathway, contributing to aging and neurodegenerative diseases.

This study shows that increasing glucose uptake in Drosophila neurons improves ATP levels, reduces aging-related deficits, and extends lifespan, especially under dietary restriction.

This study shows that a MARK4 mutation linked to Alzheimer's disease increases tau phosphorylation and neurodegeneration through both direct and indirect mechanisms.

The paper identifies RAC1 as a key gene in Alzheimer's disease progression through a protein domain network analysis and validates its role using Drosophila models and miRNA regulation.

This study identifies molecular networks and key regulators in Alzheimer’s Disease using integrative genomics and experimental validation.