HIV-1 Vpu complements HLA-A downregulation by Nef and impairs TCR-mediated recognition of HIV-infected cells through distinct mechanisms
Mariana G Bego, Tram NQ Pham, Claudia Champagne, Vandana Sharma, Melanie Laporte, Frederic Dallaire, Wes Martin, Mark A. Brockman, Frank Kirchhoff, Eric A. Cohen
This study shows HIV-1 Vpu reduces HLA-A expression and impairs TCR recognition, acting independently of Nef and requiring BST2/tetherin.
bioRxiv · Nov 5, 2026 · PreprintImmunology