COX2-independent and COX2-dependent effects of naproxen on bone quality, osteocytes, and fatigue fracture healing in male and female mice
Alexandra Ciuciu, Eric McLaughlin, Adriana Ciuciu, Kelly C Barrientos, Trenton LaPoint, Ryan E. Tomlinson
This study investigates naproxen's effects on bone quality and healing in mice, finding both COX2-dependent and -independent mechanisms with sexual dimorphism.
bioRxiv · Aug 20, 2025 · PreprintBioengineering