Ryan E. Tomlinson

This study identifies ABCC6 and ANK as regulators of extracellular pyrophosphate and citrate, showing their roles in mineral deposition and bone health, with ANK also preventing soft tissue calcification.

This study investigates naproxen's effects on bone quality and healing in mice, finding both COX2-dependent and -independent mechanisms with sexual dimorphism.

This study shows that only very high oral doses of pyrophosphate inhibit ectopic calcification in Abcc6-/- mice, but these doses harm bone structure and are impractical for human use.

This study shows that osteoblast-derived NGF is essential for bone adaptation to mechanical load and that gambogic amide requires endogenous NGF for its osteoanabolic effects in mice.

This study examines the effects of celecoxib and muMab911 on bone remodeling and fracture repair in mice, finding they suppress NGF expression and load-induced bone formation, potentially contributing to rapid osteoarthritis progression.

The paper develops a fuzzy system to optimize bioprinting parameters for different bioinks, improving precision by 15-29% compared to manufacturer recommendations.

The paper compares type-1 and type-2 fuzzy systems to optimize bioprinting parameters for bone mineralization, finding type-2 with high uncertainty boundary performs best.

This study identifies ANKH's role in extracellular citrate and pyrophosphate homeostasis and its impact on bone mechanical properties.