Direct single cell-type gene expression analysis in Whole blood: Novel ratio-based gene expression biomarkers using 2 novel monocyte reference genes (PSAP and CTSS) for monitoring bacterial infection
Nelson L.S. Tang, Tsz-Ki Kwan, Dan Yang Huang, Suk Ling Ma, Kwong-Sak Leung
The paper develops a ratio-based biomarker (DIRECT LS-TA) to quantify monocyte-specific gene expression directly from whole blood without cell sorting, showing potential for bacterial infection diagnosis.
bioRxiv · Jan 27, 2025 · PreprintImmunology