Author

Kwong-Sak Leung

Chinese University of Hong Kong

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Organism:human· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Nelson L.S. TangiD· 3 shared Dan Yang HuangiD· 2 shared Jinghan HuangiD· 2 shared Suk Ling MaiD· 2 shared Tze Hoi KwaniD· 2 shared Xingyan Wang· 2 shared Christopher KC LaiiD· 1 shared Grace Chung-Yan LuiiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersImmunology

Nelson L.S. TangORCID

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3 papers

Recent·Most cited

ImmunologybioRxivPreprintApr 13, 2026

In-silico cell sorting revealed granulocyte-specific single-cell-type gene expression from peripheral blood bulk expression data and its application as host response biomarkers to discriminate bacterial and viral infections

N. L. Tang, Tze Hoi Kwan, Jinghan Huang…·Kwong-Sak Leung

The paper develops an in-silico cell sorting method to identify granulocyte-specific gene expression biomarkers from bulk blood data, enabling discrimination between bacterial and viral infections.

DOI 10.64898/2026.04.09.717385

humanbulk RNA-seq

𝕏 PostBluesky

ImmunologybioRxivPreprintMay 8, 2025

Monocyte single cell-type gene expression measured in peripheral blood by DIRECT LS-TA method: the ratio-based biomarkers of (IFI27/PSAP) showed superior performance than interferon score in triage patients with viral infection

Nelson L.S. Tang, Tsz-Ki Kwan, Dan Yang Huang…·Kwong-Sak Leung

This paper develops a ratio-based biomarker (DIRECT LS-TA) using monocyte-specific gene expression ratios in peripheral blood to improve viral infection triage, outperforming the IFN score in diagnostic accuracy.

1 citation

humanbulk RNA-seq

𝕏 PostBluesky

ImmunologybioRxivPreprintJan 27, 2025

Direct single cell-type gene expression analysis in Whole blood: Novel ratio-based gene expression biomarkers using 2 novel monocyte reference genes (PSAP and CTSS) for monitoring bacterial infection

Nelson L.S. Tang, Tsz-Ki Kwan, Dan Yang Huang…·Kwong-Sak Leung

The paper develops a ratio-based biomarker (DIRECT LS-TA) to quantify monocyte-specific gene expression directly from whole blood without cell sorting, showing potential for bacterial infection diagnosis.

1 citation

humanbulk RNA-seq

𝕏 PostBluesky