Synaptic activity controls local exposure of an 'eat-me' signal via ANO3-ITPR1 signaling
Kunal Shroff, Molly C O'Brien, Tyler J. Smith, Jialing Fang, Kelly S Yu, Sonia I Lombroso, Shengjie Feng, Chao Chen, Gregory A. Mohl, Indigo V.L. Rose, Nidhi Rani Lokesh, Mark E. Pownall, Lily Yeh Jan, Martin Kampmann
The paper identifies ANO3-ITPR1 signaling as a caspase-independent mechanism for synaptic phosphatidylserine exposure, which controls synapse pruning during development and neurodegeneration.
bioRxiv · Jun 30, 2026 · PreprintNeuroscience