Lily Yeh Jan

WTR is a toolkit for functional anterograde transneuronal circuit mapping using a fusion protein that labels and manipulates downstream neurons.

The paper develops a method to profile synaptic proteomes under physiological conditions and identifies EGFR signaling as a key activity-dependent process at synapses.

The paper identifies ANO3-ITPR1 signaling as a caspase-independent mechanism for synaptic phosphatidylserine exposure, which controls synapse pruning during development and neurodegeneration.

The paper identifies a gene expression program in active neurons that supports sustained network activity, distinct from immediate early gene responses and enriched for excitability regulators.

This paper provides a protocol for manual whole-endolysosome patch-clamp recordings from enlarged endolysosomes in mammalian cells.

The paper identifies an atypical axon overgrowth followed by pruning in Drosophila dopamine neurons, involving AKT-GSK3β signaling and glia activity, distinct from canonical developmental remodeling.

The paper develops a cell-based phospholipid scrambling assay to show that TMEM16F preferentially scrambles phosphatidylserine and phosphatidylcholine over phosphatidylethanolamine.

The paper measures the mechanical properties of NompC gating springs and finds nonlinear compliance that may regulate mechanotransduction sensitivity.

This study develops a photo-switchable assay to study dendrite degeneration and repair in Drosophila, revealing that WldS and dSarm1 modulation affects dendrite recovery.

This paper introduces Cal-ID, a tool that records calcium signaling and neuronal activity by biotinylating nearby proteins, enabling high-resolution molecular mapping.

The paper shows steroid hormone signaling suppresses subdued expression in C4da neurons, facilitating a sensory switch from light to thermal nociception during Drosophila larval development.

The paper creates a single-cell transcriptomic atlas of the adult fruit fly, identifying over 250 cell types and analyzing gene signatures and sexual dimorphism across tissues.

This study identifies a role for the Drosophila voltage-gated sodium channel, paralytic, in regulating neural progenitor proliferation and tumor suppression.

This study uses single-cell RNAseq to identify chloride channel roles in airway development, showing their impact on differentiation and disease-like defects.

The paper identifies a behavioral plasticity in male fruit flies called Shorter-Mating-Duration (SMD) and shows it depends on specific neurons, brain regions, and neuropeptide signaling.