Pyruvate Kinase Directly Generates GTP in Glycolysis, Supporting Growth and Contributing to Guanosine Toxicity
Fukang She, Kuanqing Liu, Brent W. Anderson, Tippapha Pisithkul, Yanxiu Li, Danny Ka Chun Fung, Tyler McCue, William Mulhern, Daniel Amador‐Noguez, Jue D. Wang
The paper identifies pyruvate kinase's role in GTP synthesis during glycolysis in bacteria, showing it reduces guanosine toxicity and contributes to NTP production.
mBio · Feb 25, 2025Peer-reviewedMicrobiology