Acute E2/P4 loss compromises the biology and function of neurogenic niches during a vulnerable female aging period
Sree Vani Poorna Pillutla, Maddy J. Skoda, Atsushi Ishii, Kelsey Bernard, Mandi J. Corenblum, Tyler Montgomery, Paige V Wene, Nainika Menakuru, Jennifer N. Kraszewski, Dean D. Billheimer, Gabriel M. Winter, Stephen L. Cowen, Lalitha Madhavan
This study shows that loss of estradiol and progesterone in female rats at 9 months of age reduces neurogenesis and behavioral function, earlier than age-related declines at 14 months.
Stem Cell Reports · Feb 12, 2026Peer-reviewedNeuroscience