Lalitha Madhavan

This study shows that low-dose ketamine protects against Parkinson's-like motor deficits in rats without relying on BDNF-TrkB signaling.

This study shows that loss of estradiol and progesterone in female rats at 9 months of age reduces neurogenesis and behavioral function, earlier than age-related declines at 14 months.

This study examines bioenergetic and protein processing defects in iPSC-derived dopamine neurons from idiopathic Parkinson's disease patients, revealing impaired mitochondrial function and alpha synuclein aggregation.

This study shows that lasmiditan, a 5-HT1F receptor agonist, improves cognition and reduces pathology in aging Parkinsonian mice by enhancing mitochondrial biogenesis and reducing alpha-synuclein aggregation.

The paper identifies parallel neurodegenerative phenotypes in fibroblasts and iPSC-derived dopamine neurons from sporadic Parkinson's disease patients, revealing shared and distinct molecular and cellular alterations.

In Parkinson's disease models, alpha-synuclein overexpression sensitizes neurons to ferroptosis, potentially by suppressing NRF2 protein, while Nrf2 loss increases ferroptosis markers, alpha-synuclein pathology, and behavioral deficits.