Calcium (Ca2+) fluxes at Mitochondria-ER Contact Sites (MERCS) are a new target of senolysis in Therapy-Induced Senescence (TIS).
A. Puebla-Huerta, H. Huerta, C. Quezada-Gutierrez, P. Morgado-Caceres, C. Casanova-Canelo, S. Linsambarth, O. Diaz-Rivera, J. A. Lopez-Dominguez, S. Rodriguez-Lopez, G. Bustos, E. Silva-Pavez, A. Lovy, G. Quiroz, C. Gonzalez-Seguel, E. Salas-Huenuleo, , J. C. Cardenas
This study shows that inhibiting ER-mitochondria Ca2+ flux is a new target for senolysis in therapy-induced senescence.
bioRxiv · Mar 31, 2024Cell Biology