Author

J. A. Lopez-Dominguez

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1 Immunology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell signaling & trafficking· 3 Organism:human· 3 Assay:proteomics· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

I. Marin· 2 shared M. Serrano· 2 shared N. Prats· 2 shared A. Caballe· 1 shared A. Canella· 1 shared A. Garcia-Garijo· 1 shared A. Gros· 1 shared A. J. Covarrubias· 1 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersCancer Biology

I. Marin

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Calcium (Ca2+) fluxes at Mitochondria-ER Contact Sites (MERCS) are a new target of senolysis in Therapy-Induced Senescence (TIS).

A. Puebla-Huerta, H. Huerta, C. Quezada-Gutierrez, P. Morgado-Caceres, C. Casanova-Canelo, S. Linsambarth, O. Diaz-Rivera, J. A. Lopez-Dominguez, S. Rodriguez-Lopez, G. Bustos, E. Silva-Pavez, A. Lovy, G. Quiroz, C. Gonzalez-Seguel, E. Salas-Huenuleo, , J. C. Cardenas

This study shows that inhibiting ER-mitochondria Ca2+ flux is a new target for senolysis in therapy-induced senescence.

bioRxiv · Mar 31, 2024Cell Biology

The efficacy of chemotherapy is limited by intratumoural senescent cells that persist through the upregulation of PD-L2

S. Chaib, J. A. Lopez-Dominguez, M. Lalinde, N. Prats, I. Marin, K. Meyer, M. I. Munoz, M. Aguilera, L. Mateo, C. S.-O. Attolini, S. Llanos, M. Escorihuela, S. Perez-Ramos, F. Al-Shahrour, T. P. Cash, , M. Serrano

This study identifies PD-L2 as a marker of therapy-induced senescent cells that suppress chemotherapy efficacy, showing PD-L2 blockade enhances tumour remission in mice.

bioRxiv · Nov 4, 2022 · PreprintCancer Biology

Induction of senescence renders cancer cells highly immunogenic

I. Marin, O. Boix, A. Garcia-Garijo, i. Sirois, A. Caballe, E. Zarzuela, I. Ruano, C. Stephan-Otto Attolini, N. Prats, J. A. Lopez-Dominguez, M. Kovatcheva, E. Garralda, J. Munoz, E. Caron, M. Abad, , M. Serrano

This study shows that inducing senescence in cancer cells enhances their immunogenicity, leading to stronger anti-tumor immune responses compared to immunogenic cell death.

bioRxiv · Jun 5, 2022 · PreprintCancer Biology

Long-term ketogenic diet increases expression of SOX2-dependent oligodendrocyte- and myelination-associated genes in the aged mouse brain.

M. Stratton, J. A. Lopez-Dominguez, A. Canella, J. J. Ramsey, G. A. Cortopassi

This study finds that a long-term ketogenic diet increases SOX2-dependent oligodendrocyte and myelination gene expression in aged mouse brains.

bioRxiv · Feb 22, 2022 · PreprintPhysiology

Aging-related inflammation driven by cellular senescence enhances NAD consumption via activation of CD38+ macrophages

A. J. Covarrubias, A. Kale, R. Perrone, J. A. Lopez-Dominguez, A. Oliveira Pisco, H. G. Kasler, M. S. Schmidt, C. D. Wiley, S. S. Iyer, N. Basisty, Q. Wu, R. Kwok, I. Heckenbach, K.-O. Shin, Y.-M. Lee, , E. Verdin

This study identifies CD38+ macrophages as a driver of NAD decline during aging through inflammation linked to cellular senescence in metabolic tissues.

bioRxiv · Jul 31, 2019Immunology