Airway epithelial cells and macrophages trigger IL-6-CD95/CD95L axis and mediate initial immunopathology of COVID-19
T. F. Fraga-Silva, U. G. Cipriano, M. J. Fumagalli, G. F. Correa, C. A. Fuzo, F. L. A. C. Mestriner, C. Becari, A. Teixeira-Carvalho, J. Coelho-dos-Reis, M. G. Menegueti, L. T. M. Figueiredo, O. A. Martins-Filho, M. Dias-Baruffi, M. Auxiliadora-Martins, R. C. Tostes, V. L. D. Bonato
This study identifies the IL-6-CD95/CD95L axis as a key driver of immunopathology in severe COVID-19 through interactions between airway epithelial cells and macrophages.
bioRxiv · Aug 22, 2022Immunology