This study shows that high testosterone increases NOX4 in endothelial cells, boosting H2O2 production to counteract testosterone-induced endothelial dysfunction and impaired migration.

bioRxiv · Aug 30, 2023Pharmacology & Toxicology

Airway epithelial cells and macrophages trigger IL-6-CD95/CD95L axis and mediate initial immunopathology of COVID-19

T. F. Fraga-Silva, U. G. Cipriano, M. J. Fumagalli, G. F. Correa, C. A. Fuzo, F. L. A. C. Mestriner, C. Becari, A. Teixeira-Carvalho, J. Coelho-dos-Reis, M. G. Menegueti, L. T. M. Figueiredo, O. A. Martins-Filho, M. Dias-Baruffi, M. Auxiliadora-Martins, R. C. Tostes, V. L. D. Bonato

This study identifies the IL-6-CD95/CD95L axis as a key driver of immunopathology in severe COVID-19 through interactions between airway epithelial cells and macrophages.

bioRxiv · Aug 22, 2022Immunology

Baroreceptor denervation reduces inflammatory status and worsens cardiovascular collapse during systemic inflammation

M. R. Amorim, J. L. de Deus, C. A. Pereira, L. E. V. da Silva, G. S. Borges, N. S. Ferreira, M. E. Batalhao, J. Antunes-Rodrigues, E. C. Carnio, R. C. Tostes, L. G. Branco

This study shows that baroreceptor denervation increases cytokine levels but worsens cardiovascular collapse during systemic inflammation in rats.

bioRxiv · Aug 29, 2019Immunology