Author

U. Gruneberg

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 9

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Research Focus:cell signaling & trafficking· 9 Approach:experimental assay· 9 Research Focus:chromatin & epigenetic regulation· 6 Organism:human· 4 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Research Focus:development & morphogenesis· 1 Assay:protein sequence· 1

Frequent Co-Authors

D. Hayward· 5 shared F. A. Barr· 3 shared E. Roberts· 2 shared J. Bancroft· 2 shared T. Alfonso-Perez· 2 shared Z. Geraghty· 2 shared A. Gluszek-Kustusz· 1 shared C. Barnard· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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5 shared papersCell Biology

D. Hayward

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9 papers

Recent·Most cited

Spindle checkpoint signalling in anaphase is prevented by KNL1 release from kinetochores

I. Lim-Manley, U. Gruneberg

The paper shows CDK1-mediated KNL1 recruitment to kinetochores is reversed by PP1 phosphatase at metaphase-to-anaphase transition, leading to SAC termination.

bioRxiv · May 10, 2023 · PreprintCell Biology

Regulated Degradation of the Inner Nuclear Membrane Protein SUN2 Maintains Nuclear Envelope Architecture and Function

L. Krshnan, W. S. Siu, M. Van de Weijer, D. Hayward, E. N. Guerrero, U. Gruneberg, P. Carvalho

This study identifies a degradation mechanism for SUN2, an inner nuclear membrane protein, showing that its regulated turnover is essential for maintaining nuclear envelope structure and function.

bioRxiv · Jul 15, 2022Cell Biology

PP6 regulation of Aurora A-TPX2 limits NDC80 phosphorylation and mitotic spindle size

T. Sobajima, K. Kowalczyk, S. Skylakakis, D. Hayward, L. J. Fulcher, C. Neary, C. Batley, S. Kurlekar, E. Roberts, U. Gruneberg, F. A. Barr

The paper shows that PP6 regulates Aurora A-TPX2 to control NDC80 phosphorylation and mitotic spindle size, preventing defective nuclear structure.

bioRxiv · May 23, 2022Cell Biology

MPS1 localizes to microtubule-attached kinetochores and actively promotesmicrotubule release

D. Hayward, E. Roberts, U. Gruneberg

The paper shows MPS1 localizes to microtubule-attached kinetochores and actively promotes microtubule release, challenging the model of MPS1 as a passive sensor.

bioRxiv · May 23, 2022 · PreprintCell Biology

The association of Plk1 with the Astrin-Kinastrin complex promotes formation and maintenance of a metaphase plate

Z. Geraghty, C. Barnard, P. Uluocak, U. Gruneberg

This paper shows that Plk1 binds to and phosphorylates Astrin, promoting kinetochore recruitment and stable microtubule-kinetochore attachments during metaphase.

bioRxiv · Jul 1, 2020Cell Biology

PP1 promotes cyclin B destruction and the metaphase-anaphase transition by dephosphorylating CDC20

J. Bancroft, J. Holder, Z. Geraghty, T. Alfonso-Perez, D. Murphy, F. Barr, U. Gruneberg

The paper shows PP1 dephosphorylates CDC20 to promote cyclin B destruction and the metaphase-anaphase transition in human cells.

bioRxiv · Jun 22, 2020Cell Biology

The C-terminal helix of BubR1 is essential for CENP-E-dependent chromosome alignment

T. Legal, D. Hayward, A. Gluszek-Kustusz, E. BLACKBURN, C. Spanos, J. Rappsilber, U. Gruneberg, J. P. Welburn

This study identifies the molecular interaction between BubR1 and CENP-E required for CENP-E recruitment to kinetochores and chromosome alignment during mitosis.

bioRxiv · Feb 25, 2020Cell Biology

Aurora A promotes chromosome congression by activating the condensin-dependent pool of KIF4A

E. Poser, R. Caous, U. Gruneberg, F. A. Barr

The paper shows Aurora A phosphorylates the condensin I-dependent pool of KIF4A, promoting chromosome congression during mitosis.

bioRxiv · May 27, 2019Cell Biology

Checkpoint signaling and error correction require regulation of the MPS1 T-loop by PP2A-B56

U. Gruneberg, D. Hayward, J. Bancroft, D. Mangat, T. Alfonso-Perez, S. Dugdale, J. McCarthy, F. A. Barr

The paper shows that PP2A-B56 regulates MPS1 T-loop autophosphorylation, controlling MPS1 activity and mitotic progression.

bioRxiv · May 3, 2019Cell Biology