Flotillin-2 regulates EGFR activation, degradation, and cancer growth
D. J. Wisniewski, M. S. Liyasova, S. Korrapati, X. Zhang, S. Ratnayake, Q. Chen, S. F. Gilbert, A. Catalano, D. Voeller, D. Meerzaman, U. J. Guha, N. Porat-Shliom, C. Annunziata, S. Lipkowitz
This study shows that Flotillin-2 negatively regulates EGFR activation, ubiquitination, trafficking, and degradation, thereby suppressing cancer growth.
bioRxiv · Mar 11, 2022 · PreprintCancer Biology