D. Meerzaman

The ESCRT protein CHMP5 promotes T cell leukemia by controlling BRD4-p300-dependent transcription

This paper identifies CHMP5 as a nuclear factor that promotes T cell leukemia by enhancing BRD4-p300-dependent transcription at enhancers and super-enhancers.

Timp2 loss-of-function mutation and TIMP2 treatment in murine model of NSCLC: modulation of immunosuppression and oncogenic signaling

TIMP2 treatment compensates for TIMP2 mutation to reveal immunomodulatory and oncogene regulation that inhibits tumor growth and metastatic niche formation.

Flotillin-2 regulates EGFR activation, degradation, and cancer growth

This study shows that Flotillin-2 negatively regulates EGFR activation, ubiquitination, trafficking, and degradation, thereby suppressing cancer growth.

Whole Organism Profiling of the Timp Gene Family

The paper analyzes Timp gene expression across healthy tissues using single-cell RNA sequencing to identify cell-type-specific patterns and expand on these findings with RNA in-situ hybridization.

Internal checkpoint regulates T cell neoantigen reactivity and susceptibility to PD1 blockade

This study shows that CISH knockout in TIL enhances neoantigen reactivity and synergizes with PD1 blockade to improve tumor regression.

BRD4 Deficiency Selectively Affects a Unique Developmental Subpopulation in Thymocytes

This study shows BRD4 is critical for T cell development, specifically regulating immature CD8 single-positive thymocytes' progression to double positive thymocytes, while not affecting other stages.